Vol. 16, No. 3Abnormality Detection in Correlated Gaussian Molecular Nano-Networks: Design and Analysis
A nano-abnormality detection scheme (NADS) in molecular nano-networks is studied. This is motivated by the fact that early detection of diseases such as cancer plays a crucial role in their successful treatment.
Vol. 16, No. 3Use of Model Predictive Control and Artificial Neural Networks to Optimize the Ultrasonic Release of a Model Drug From Liposomes
The use of echogenic liposomes to deliver chemotherapeutic agents for cancer treatment has gained wide recognition in the last 20 years. Cancerous cells can develop multiple drug resistance (MDR), in part, due to the drop in concentration of chemotherapeutic agents below the therapeutic levels inside the tumor.
Vol. 16, No. 2Introduction to the Special Issue on Bioinformatics Research and Applications
This special issue includes a selection of papers presented at the 12th International Symposium on Bioinformatics Research and Application (ISBRA), which was held at Belorussian State University in Minsk, Belarus on June 5-8, 2016.
Vol. 16, No. 2A Framework for Integrating Multiple Biological Networks to Predict MicroRNA-Disease Associations
MicroRNAs have close relationship with human diseases. Therefore, identifying disease related MicroRNAs plays an important role in disease diagnosis, prognosis and therapy. However, designing an effective computational method…
Vol. 16, No. 2HapIso: An Accurate Method for the Haplotype- Specific Isoforms Reconstruction From Long Single-Molecule Reads
Sequencing of RNA provides the possibility to study an individual’s transcriptome landscape and determine allelic expression ratios. Single-molecule protocols generate multi-kilobase reads longer than most transcripts…
Vol. 16, No. 2OVarCall: Bayesian Mutation Calling Method Utilizing Overlapping Paired-End Reads
Detection of somatic mutations from tumor and matched normal sequencing data has become a standard approach in cancer research.